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Kavazis, A

FIGURE 3 A high concentration of Se compounds also performs a redox-active act as prooxidants, generating ROS in reaction (Table 1), SeMet could inhibit cell proliferation by inducing ROS generation and activating apoptosis cellular proteins, including the caspase family and p53 ( 2 downregulated Bcl-2 survival genes in lung cancer cell lines ( The current research on Se compounds focuses on both sides of the spectrum: the protective effect against cell damage or the anti-proliferation effect against cancer cell lines

To overcome the "absorption gap," advanced delivery methods are required

Therefore, for a ROS-mediated therapeutic approach to be effective, this therapy must limit ROS production when ROS would induce proliferation, and it must promote ROS production when ROS would induce apoptosis

NAC is a widely used drug, primarily as an antidote for acetaminophen overdose, but possesses many other beneficial effects, including correcting the oxidative stress-mediated ELS dysfunction, suggesting that it may reverse some neurological complications of HAND (Tripathi et al., 2020)

Accessed August 23, 2025