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This involves strengthening ethics committees but also reminding and highlighting a rule that has been in place since 1959: the 3Rs 1,2

fertilization is external, making it possible to collect eggs for studies such as toxicological tests, and its embryos are transparent, which allows the entire embryonic development to be visualized, observing its organs, heartbeat, and movement of the bloodstream

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Unique ligand-receptor partners were identified in age (ADIPONECTIN, MK, CNTN), alcohol (ADGRB, NT, EPHA), or in the aged alcohol group (SPP1, MSTN, NRXN)

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