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Future studies should focus on identifying its active constituents, elucidating detailed mechanisms of action, and validating its efficacy in well-designed clinical trials

However, that doesnt mean everyone needs it, said Dr Saraf

At the same time, it downregulates the expression of multiple drug efflux pumps in tumor cells, thereby reversing multidrug resistance (MDR) and increasing the intracellular accumulation and cytotoxicity of chemotherapeutic agents such as cisplatin, paclitaxel, and 5-FU (Ghosh et al., 2022)

Among these, the MTHFR C677T variant has been most extensively studied, although findings from individual studies remain inconclusive, possibly due to underpowered cohorts [89, 90]

Dissolved peptides can also aggregate, oxidize, or lose their structure over time, and depending on the solvent, may end up as a gel or cloudy solution

Since cPMP replacement therapy can only benefit MocoD Type A, additional treatment methods are required