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The effects of NO are highly dose-dependent: while physiological levels are cytoprotective, excessive NO can react with superoxide to form peroxynitrite, exacerbating oxidative injury 22,23

194 PRMT7 can promote the transcription of Oct4, c-Myc, Nanog, and Klf4 by regulating the histone methylation of miR-24-2 and miR-221 promoters and inhibiting the expression of miRNA

After different combinations of plasmids were transfected into H9C2, it was observed that compared with WT group, relative luciferase activity was significantly decreased in oe-Sox2 + WT group (Figure 8H)