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The reliance on natural sunlight and specific temperature requirements restricts commercial Spirulina production in open ponds to tropical and subtropical regions, limiting wider global production and potentially increasing transportation costs

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However, a lack of organelles, especially mitochondria, limits the cell death machinery of mature erythrocytes and their ability to undergo specific, regulated cell death modes

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Although relatively few proteins are lipoylated in mammalian cells, all lipoylated proteins are involved in the TCA cycle