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In end-stage renal disease IGF-1 level is normal or decreased and levels of IGF binding proteins (IGFBP) are increased, thus resulting in a net decrease in IGF bioactivity

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doi: 10.1007/s00401-016-1545-1 3 MichalskiJMJanssAJVezinaLGSmithKSBillupsCABurgerPCet al

J Med Microbiol 69(1):104110 Khan I, Saeed K, Khan I (2019) Nanoparticles: properties, applications and toxicities

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