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Methods This systematic review was conducted and presented according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) guidelines (Supplementary Table S1) and Assessment of Multiple Systematic Reviews 2(AMSTAR 2) tools (Supplementary Table S2)

Under oxidative stress, certain cysteine residues on KEAP1 undergo chemical modifications that decrease NRF2 binding affinity, thus facilitating the expression of protective redox-related genes [89]

Previous studies have shown that AIF KO mice are embryonically lethal 15

A meta-analysis of adult studies on AIH showed poor sensitivity (ANA: 65%, ASMA: 59.3%) and reasonably good specificity (ANA: 75.1%, ASMA: 92.6%) of ANA and ASMA for the diagnosis of AIH [57]

The large heterogeneity for some outcomes, such as CAD, may suggest different mechanisms underlying the genetic associations or the existence of pleiotropy [37]

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