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Heavy alcohol use is a major cofactor that significantly raises the risk of HCC in patients with HBV-related cirrhosis

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183 It is therefore important to recognise the potential likelihood of neuropathy induced by vitamin B 12, occurring or being exacerbated as a result of the co-prescription of medications commonly used to treat these co-morbidities, particularly since they are typically long-term drug treatments

Stability can be affected by formulation, storage, heat and oxidation