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NF-kB (nuclear factor-kB) is a transcription factor that regulates many immune and inflammatory response genes.[ref] It can turn up the heat at times when inflammatory cytokines, such as IL-6, IL-13, and TNF-alpha , are needed.[ref] NF-kB also regulates melatonin production in the pineal gland and in cells that produce melatonin

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Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm