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Off-label applications are reported only by practitioners and require oversight by the care team

Portions of the Graphical Abstract and Figs

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Given the brains unique susceptibility to proteotoxic stress, owing to its post-mitotic neuronal population, high metabolic demand, and reliance on precise proteome regulation, UPS integrity is indispensable for neuronal survival

This approach also maintained the integrity of key EV surface markers while also giving insights on the size distribution and purity of the isolated EVs