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moreover, a meta-analysis of previous randomized trials showed a reduction in total cancer mortality with supplementation (68)

This role is vital in preventing cellular damage and maintaining cellular health

Some lifestyle, diet, and supplement choices have been associated with increased BH4

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These possible side effects should be considered when therapeutics for NP are developed in the future

Tumor cells exploit this through a process called tumor cell-induced platelet aggregation (TCIPA) [58]