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Vitamin D improves hepatic steatosis in NAFLD via PPAR signaling

Although the [U- 13 C]glucose isotope-labeling assay showed slightly increased incorporation of [ 13 C]glucose-derived carbons into glutamate (Figure 3A), -ketoglutarate (-KG) (Figure 3C), and GSH (Figure 3E) as well as GSSG (Figure 3G), the relative levels of overall glutamate (Figure 3B), -KG (Figure 3D), and GSH (Figure 3F) among all detected metabolites decreased

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Analysis of novel sources of genetic contributions to CAS Three forms of genetic analysis for CAS that have not been previously applied were undertaken: (1) short tandem repeat (STR) analysis of both known and novel pathogenic repeats (Supplementary Table 3)

The authors showed that liver nuclei from three species tested (rat, hamster and mouse) were able to promote a lipid peroxidation process in the presence of carbon tetrachloride, and that NADPH was only required in part for carbon-tetrachloride-induced lipid peroxidation in the case of the mice