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This anion then quickly breaks a disulfide bond (Cys58 - Cys63) and leads to Cys63's nucleophilically attacking the nearest sulfide unit in the GSSG molecule (promoted by His467), which creates a mixed disulfide bond (GS-Cys58) and a GS-anion

D.RaadsenM

The structure of GPCRs consists of a single polypeptide chain comprising of seven transmembrane helices, where N-terminal domain is extracellular and C-terminal is located intracellularly

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Yin H, Ma J, Han J, et al

Baseline characteristics included 32% with hypertension, 30% with dyslipidemia, 8% with obstructive sleep apnea, and 3% with cardiovascular disease