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Description

Yu et al

Semaglutide, the GLP-1 agonist behind Ozempic and Wegovy, is the most direct comparator to tirzepatide

This suggests its metabolic influence is primarily on fat oxidation rather than muscle catabolism

Long-Term Long-term considerations are different, as semaglutide has multi-year data on sustained weight loss and metabolic benefit, although weight regains occur if therapy ceases