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For instance, the methylation pattern of APOE was found to be of a bimodal structure, ranging from a hypomethylated CpG-poor promoter to a fully methylated 3-CpG-island [146]

As an example, Cd, Pb, and Cr are known to induce thyrotoxicosis (Qureshi and Mahmood, 2010)

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(3) Y Asadi, R K Moundounga, A Chakroborty, A Pokokiri, and H Wang (2025) FOXOs and their roles in acute and chronic neurological disorders Frontiers in Molecular Bioscience

[DOI] [PMC free article] [PubMed] [Google Scholar] Colon EJ

This includes any sign, symptom, illness, or abnormal laboratory result that arises during the trial period