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Abbreviations PD: Parkinsons disease NAC: N-acetylcysteine GSH: Glutathione GSSG: Glutathione disulfide UPDRS: Unified Parkinsons Disease Rating Scale CSF: Cerebrospinal fluid DAT: Dopamine transporter MRS: Magnetic resonance spectroscopy MPP: 1-methyl-4-phenylpyridinium MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ADL: Activities of daily living MoCA: Montreal cognitive assessment 4-HNE: 4-hydroxynonenal 6-OHDA: 6-hydroxydopamine L-DOPA: Levodopa ECG: Electrocardiogram SPECT: Single-photon emission computed tomography PROMIS: Patient-reported outcomes measurement information system PDQ-39: Parkinsons Disease Questionnaire-39 PRO-PD: Patient-reported outcomes in Parkinsons disease H&Y: Hoehn and Yahr MMSE: Mini-mental state examination CBC: Complete blood count ALT: Alanine aminotransferase AST: Aspartate aminotransferase BUN: Blood urea nitrogen SOD: Superoxide dismutase MCID: Minimal clinically important difference SD: Standard deviation References Ball N, Teo W-P, Chandra S, Chapman J (2019) Parkinsons disease and the environment

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Wei Z., Hao C., Huangfu J., Srinivasagan R., Zhang X., Fan X

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Together, these findings highlight histone crotonylation as a stress-sensitive epigenetic mechanism that regulates synaptic plasticity and depressive-like behaviors, primarily via CDYLEZH2VGF signaling