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Smad2 and Smad3 inversely regulate TGF- autoinduction in Clostridium butyricum-activated dendritic cells

Although the exact mechanism leading to this outcome is undetermined, gene susceptibility and brain infection by several microorganisms has been associated with the pathogenesis of AD, such as for Chlamydophila pneumonie (Grard et al., Borrelia burgdorferi (Miklossy, 2011) and HSV-1 (Itzhaki, 2014, 2016), among others (Lurain et al., 2013

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However, despite the improvements in folate production by microorganisms that have been achieved, the industrial microbial production of folate is still far from being economically feasible due to very low yields