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In recent decades, our understanding of tumors has been revolutionized, and we have discovered that tumors are complex ecosystems, the concept of tumors has shifted from a purely confined disease centered on tumor cells to a disease in which a variety of non-tumor cells interact with each other within the tumor [142]

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The PEP-3 includes a performance aspect, which is administered by direct testing and observation, and a caregiver report

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However, chronic (several weeks), oral BH 4 administration gave slightly discrepant results

Menon D, Barnett C, Bril V