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Once maintenance doses were reached, gastrointestinal symptoms typically stabilized at more manageable levels

Medical literature suggests a strong biologic plausibility between opioid analgesics and OIH and allodynia

In most cases, this is a consequence of weakening of muscles in the area of injection that are involved in breathing or oropharyngeal muscles that control swallowing or breathing (see Boxed Warning )

Vitamin B12 supplementation is often needed because the stomachs intrinsic factor, which helps absorb B12, may be affected

Cell experiments and controlled experimental animal models can help researchers study possible mechanisms, but they cannot establish safety or effectiveness for human or veterinary use