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falciparum 3D7 following treatment with DFO and DHA Artemisinin exerts parasiticidal effects after activation by iron or heme, whereas iron chelators (e.g., DFO) likely kill parasites by disrupting iron utilization

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Animal models are used as they can fill the gap that in vitro models often have, viz, the lack of physiological resemblance

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Current DSIP research appears to be dominated by preclinical, mechanistic, and exploratory work rather than large modern human outcome trials [2]