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6 CAR T-cell therapy toxicities: CRS, neurotoxicity, and management strategies While CAR T-cell therapy shows great therapeutic promise, it is also associated with serious toxicities, particularly CRS and immune effector cell-associated neurotoxicity syndrome (ICANS), which have become major safety challenges in clinical applications

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Discovery of (R)-N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a novel orally bioavailable EAAT2 modulator with drug-like properties and potent antiseizure activityin vivo