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In the context of FPN deficiency or inadequate expression, the cells cannot efficiently export iron, resulting in continued accumulation of free iron and further enhancing the detrimental effects of ferroptosis

Discussion ALS-related SOD1 mutations are distributed throughout the molecules structure with two exceptions: the disulphide sub-loop and the -strand 3

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In addition, levocarnitine treatment increased calcium and phosphate levels and was not associated with parathyroid hormone or fibroblast growth factor 23 [94,95]

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This energy deficiency directly limits T cell proliferation capacity, thereby weakening their ability to effectively respond to tumor cells and other immune challenges (90)