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Early cell-culture work in a human melanoma line reported that BPC-157 actually inhibited cell growth and attenuated VEGF signaling by reducing ERK phosphorylation via the MAPK pathway an anti-mitogenic rather than pro-tumor effect in that specific model

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The effect of pentadecapeptide BPC 157, H2-blockers, omeprazole and sucralfate on new vessels and new granulation tissue formation

In the 15-year study, researchers noted not only a lack of adverse events in patients treated with epithalamin, but also found that patients treated with the peptide had significantly lower mortality compared to the patients in the control group [12]

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