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In comparison, the average improvement of the VAS scores for the placebo group was only 3%

10.4097/kja.19259 37

So the Tesamorelin GH-IGF-1 axis still produces a real downstream signal at 12 weeks, at 26 weeks, and at 52 weeks of continuous use

10.1093/biolre/ioaf123 Biol

Decreases appetite and reduces cravings Promotes weight loss Lowers A1C levels (a marker of blood sugar control) Enhances insulin sensitivity 1 Improves cardiometabolic health measures 4 The medication is not insulin