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Unlike GLS1, GLS2 is not inhibited by CB-839 or glutamate (its immediate byproduct), and can directly bind and inhibit Rac1 (Ras-related C3 botulinum toxin substrate 1), suppressing murine and human hepatocellular carcinoma cells migration and metastasis in a mouse model [205]

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25 , E1E13 (2012)

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Glutathione IV therapy can provide vital nutritional support to those dealing with critical illnesses or severe infections, helping to maintain muscle mass by preventing muscle wasting, a common occurrence in such individuals

Different tumors utilize Gln in distinct ways, which means that Gln inhibitors may have varying roles across different tumor types