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Zebrafish xenograft models faithfully replicate conserved metastatic mechanisms documented in murine models, including evolutionarily maintained signaling pathways (e.g., HTR2A/2B-mediated EMT induction (111)) and prototypical metastatic cascades such as hematogenous dissemination

CDGSH Iron Sulfur Domain 2 ( CISD2 ) has been identified as a crucial gene in RM, serving as a significant therapeutic target associated with ferroptosis

Xie H, Zhou J, Liu X, Xu Y, Hepperla AJ, Simon JM, et al

This study was conducted in accordance with the World Medical Association Code of Ethics

Placebo effects in osteoarthritis: implications for treatment and drug development

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