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Use in humans is not approved outside research

Phosphorylation of IRF3 by TBK1 dimerizes and translocates IRF3 to the nucleus, inducing the expression of the type I interferon (IFN) gene, interferon-stimulated genes (ISGs), and several other inflammatory mediators, pro-apoptotic genes, and chemokines, which in turn are involved in various pathophysiological processes (141, 145, 146) ( Figure 2 )

In this study, again due to small sample size, we did not limit our analysis to those strokes of a particular etiology but rather focused upon the entire group

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Tighe-Neira R, Carmora E, Recio G, Nunes-Nesi A, Reyes-Diaz M, Alberdi M, et al

More significant metabolic changes were found after 8 weeks than 4 weeks post baseline