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Mitochondrial biogenesis is another critical component of MQC, involving DNA replication, transcription, translation, and phospholipid transport between organelles

Leptin interferes with the insulin signaling pathway, leading to impaired glucose and lipid metabolism, and promotes liver fat accumulation, which is characteristic of MASLD [213, 214]

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Astrocytes derived from ALS post-mortem tissues trigger the death of neurons in co-cultures 237,238 , whereas transplantation of astrocytes derived from pluripotent stem cells obtained from patients with ALS into the spinal cord of mice resulted in the degeneration of motor neurons and motor deficits 239