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105 These findings imply that oxidized POLG causes mtDNA mutation or depletion and in turn results in a variety of diseases

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Research on animals has shown that low levels of melatonin, when taken over a prolonged period, may counteract the ageing process by reversing and stabilizing the negative effects it has on oxygen and energy metabolism (Okatani et al

For example, sulfasalazine, a clinically used ferroptosis inducer, is very effective against thyroid cancer cells, indicating its possible use in TAO (367, 368)

The sst 2 subtype is primarily involved in preventing the acute stress-induced endocrine (rise of ACTH and corticosterone), autonomic (sympatho-inhibition) and behavioral (suppression of food intake and anxiety) responses