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Free Radic Biol Med (2005) 38(12):154352

Additionally, berberine enhanced apoptosis of colonic macrophages and decreased proinflammatory cytokine production in colonic macrophages and epithelial cells of DSS-treated mice

Bibcode:2017PNAS..114E7348P

While the tyrosine kinase activity of IGF-1R is needed for downstream AKT activation, MAPK activation takes place without it (60), requiring in this case the C-terminal region of the receptor (61)