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Thus, according to positron emission tomography (PET), isoflurane anesthesia can cause a 50% decrease in the rate of glucose uptake by the brain (Alkire et al., 1995, 1997), which leads to a sharp inhibition of aerobic oxidation in the cells and development of severe hypoxia, decreased neuronal activity (Hodes et al., 1985), and the appearance of amyloid in the brain 6-24 h after application of the anesthetic (Xie et al., 2006a, 2008)

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Nevertheless, perthiyl radicals have a fleeting (almost diffusion-limited) existence, as they have a strong tendency to recombine with each other

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