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However, with growing interest in the neurobiology of heavy metals, Mn has now been linked to other major neurodegenerative diseases such as HD and prion diseases (Martin et al., 2011

Gene 212 , 7786 (1998)

Glutathione is a small protein naturally produced in every cell of the body

The enzyme PHD2 was therefore identified as a critical Mn sensor that controls Mn homeostasis upon Mn overload

While the committee's recommendations are influential, they are advisory rather than binding