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Inhibitory effect of brazilein on tyrosinase and melanin synthesis: Kinetics and in silico approach

Researchers requiring an individual product format may also review GHK-Cu

Exclusion criteria: (1) Patients with abnormal coagulation function [limits: prothrombin time (PT) between 1014 seconds, activated partial thromboplastin time (APTT) between 2540 seconds, and fibrinogen (Fib) levels between 2.04.0 g/L] and immunodeficiency [either primary immunodeficiency (congenital or hereditary conditions leading to impaired immune responses) or secondary immunodeficiency (conditions acquired through HIV infection, chronic immunosuppressive therapy, or severe malnutrition)]

This sustained elevation is what inhibits melanogenesis: glutathione competitively inhibits tyrosinase (the rate-limiting enzyme in melanin synthesis) and shifts melanin production from eumelanin (brown-black pigment) toward pheomelanin (red-yellow pigment), resulting in visible skin lightening over 612 weeks of biweekly administration

The nausea at higher doses without adequate adaptation can be severe enough to force protocol abandonment entirely

The results showed that the pharmacokinetic characteristics of BPC15 were consistent with the general properties of peptide drugs