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Computer-aided design of -L-rhamnosidase to increase the synthesis efficiency of icariside I

We propose that restoring cellular voltage, reducing tissue hypoxia, and mechanically forcing detoxification pathways is the essential prerequisite for biochemical interventions to be effective

(1) Groups at Risk of a Potential Vitamin B12 Deficiency Some people are at a higher risk for B12 deficiency, including those who: Have celiac disease, Crohns disease (a gastrointestinal disorder that can impact B12 absorption), or HIV Regularly take antacids, proton pump inhibitors, or other gastric acid inhibitors (these medications reduce gastric acid secretion and can interfere with vitamin B12 absorption, increasing deficiency risk) Follow vegan diets (vegan diets lack sufficient vitamin B12 sources, as B12 is mainly found in animal products) Are exclusively breastfed infants of women on vegan diets (these infants are at risk of B12 deficiency due to low maternal B12 intake)

Acknowledgements We thank the Swanson Biotechnology Center at the Koch Institute, including the Flow Cytometry, Histology, and ES Cell and Transgenics core facilities

C.de Souza Duro JuniorM.et al (2016)

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