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Vitamin B12 plays a vital role in red blood cell production, nerve function, and cellular energy

Blood 140:152156 Zerbit J, Detroit M, Meyer A, Decroocq J, Deau-Fischer B, Deschamps P, Birsen R, Mondesir J, Franchi P, Miekoutima E (2022) Patients with hematological malignancies treated with T-cell or B-cell immunotherapy remain at high risk of severe forms of COVID-19 in the omicron era

Voltage gated calcium channels and chemical channels (i.e., glutamate) are well known calcium channels (Kumar et al., 2017)

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Once the microglia engulf the senescent neurons, they become senescent, dysfunctional and amplify pathogenesis through inflammation, releasing toxic tau and failure to survey the brain microenvironment