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However, it is most commonly used by those with experience in structured supplementation

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Thiamine is involved in the Krebs cycle, riboflavin in the electron transport chain, and niacin plays a key role in both glycolysis and the Krebs cycle

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For example, sugar alcohols like sorbitol or mannitol (used in some chewable or effervescent preparations) can have osmotic effects, drawing water into the intestinal lumen and potentially leading to loose stools in sensitive individuals