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Furthermore, research indicates that quercetin exerts its anti-inflammatory effects by inhibiting the expression of cytokines and nitric oxide synthase, which is mediated by the suppression of the NF-B pathway, while not affecting the activity of terminal-c-Jun N kinase

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This epigenetic reprogramming induces immunosuppressive phenotypes in immune cells that are resident in the tumor microenvironment, including impaired effector function, enhanced immunosuppressive cytokine secretion, and altered tumor antigen presentation, collectively facilitating immune escape

Phytochemicals consist of both primary and secondary metabolites (212)

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Correspondingly, pathway enrichment analysis with GO and KEGG reveal that the inhibition of FA metabolic process, lipid catabolic process and FA degradation could be relieved with CBD treatment upon IR exposure (Fig