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Physical exercise and particular nutrients, including CIT and leucine, have demonstrated efficacy in upregulating the signaling pathways of PGC-1, SIRT1, and AMPK, thereby facilitating mitochondrial turnover and alleviating oxidative stress (74)

Abstract Background Hepatitis C virus (HCV) infection, a systemic disease characterized by extrahepatic manifestations (EMs), affects approximately 50 million people worldwide