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[6] The reaction mechanism of the P-450 oxidases proceeds through the reduction of cytochrome-bound oxygen and the generation of a highly-reactive oxyferryl species, according to the following scheme: [7] Phase II - conjugation [edit] In subsequent phase II reactions, these activated xenobiotic metabolites are conjugated with charged species such as glutathione (GSH), sulfate, glycine, or glucuronic acid

In Part I we discussed the potential role of the COMT gene in disorders such as schizophrenia, bipolar disorder and possibly ME/CFS and that the RORA gene may help explain the gender imbalance in ASD

Access this article Similar content being viewed by others Change history 26 August 2017 An erratum to this article has been published

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This is supported by reductions in neuroinflammatory mediators, including TNF-, IL-1, and iNOS, alongside the downregulation of TLR4 transcriptional regulators, such as p-c-Jun and PU.1 [171]

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