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doi: 10.1016/j.freeradbiomed.2021.12.012

In a rat model of adjuvant-induced arthritis, the combination of metformin (200 mg/kg/day) and omega-3 (300 mg/kg/day) showed efficacy comparable to methotrexate (2 mg/kg/week) in ameliorating disease activity, with significant reductions in arthritic scores, paw swelling, and serum TNF- and IL-1 after 4 weeks (252)

Carrizzo et al

Each image matrix was then resized to 120 100 for clarity

Analysis of serum anti-RBD antibody titers at day 14 post-immunization revealed that anti-CD25 administration at days 1, 0, or 1 relative to vaccination significantly enhanced antibody titer compared to vaccine-alone group

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