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In addition to breaking down histamine, DAO is also responsible for breaking down other biogenic amines (including serotonin, tyramine and putrescine)

Tumor necrosis factor-alpha (TNF-)and Interleukin-1 (IL-1) as well as other cytokines involved in homeostasis or neuroinflammation and illness, are produced by microglia [34]

Glycogen metabolism regulates macrophage-mediated acute inflammatory responses

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Also, CB indirectly assists immune tolerance by upregulating retinol metabolism, reducing pro-inflammatory microbiota (77), and regulating intestinal permeability via miR-200c (80)