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Coordinated remodeling of the TDLN environment by tumor cells leads to a pre-metastatic niche. ( Early studies suggested that lymphocytes isolated from TDLN are more active than lymphocytes in other compartments, with increased IL-2 production and cytotoxicity ( 4 Early metastasis to the TDLN When tumor cells disseminate to the lymph node, they may be destroyed, continue their journey into the efferent lymphatic fluid, or remain in the lymph node and form metastases

Missing values for each group are imputed using the nearest neighbour method after removing peptides missing in more than two

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Furthermore, pS422 tau and tau oligomers (TOC1) also colocalize with PAD-exposed tau in human tauopathy brains 34,67

doi: 10.1016/j.bj.2015.06.002, 55