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KDM4C bound directly to the cFLIP promoter, and Gln deprivation did not inhibit KDM4C binding to the cFLIP promoter, indicating that Gln deprivation inhibits the activation of KDM4C-mediated cFLIP transcription by reducing the level of aKG, which is required for KDM4C activity (Fig

Similarly, the tumor microenvironment (TME) can induce epigenetic alterations in cancer cells, affecting the behavior of cancer cells, such as the promotion of cancer stemness