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The mechanisms that may contribute to the induction of oxidative damage in diabetic patients include hyperglycemia-induced glucose auto-oxidation, non-enzymatic glycation of proteins and lipids, increased sorbitol pathway activity, oxidation of AGEs, and formation of prostaglandin H2 (PGH2) [311]

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By activating SIRT-1 and down-regulating NF-B activation, RSV plays a vital role in the regulation of inflammation that mediates colitis and colon cancer (145) ( Supplementary Table 1 )

Two case-control studies suggested that hypothyroidism represents a risk factor for HCC

Additionally, MNAM has a low permeability to the membrane, which is crucial for achieving the desired therapeutic effect of the drug (Neelakantan et al., 2018)

In fact, psychologically or physically stressed rodents exhibit worse symptoms of colitis 47,48,49,50