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Cytokine modulation : IVIG helps regulate pro-inflammatory and anti-inflammatory cytokines, restoring immune balance

Protocol 4: nasal spray approach Goal: Needle-free administration with acceptable bioavailability trade-off Duration: 20 days active, then 4-6 months off Schedule: Days 1-20: 10-15 mg epitalon intranasally, divided into 2-3 daily doses Days 21-180: Off cycle Repeat 1-2 times per year Formulation: Reconstitute in saline with 3 percent DMSO for improved nasal absorption

Methods : Cases from the Spanish and Latin American DILI registries were included

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Translational medicine Interference with indirect Coombs tests As CD38 is widely expressed on RBCs, both isatuximab and daratumumab can interfere with indirect Coombs tests used for blood compatibility testing [46, 47]

developed a PEGylated form of catalase (CAT-PEG) to enhance its stability and bioavailability in vivo