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doi: 10.7759/cureus.84101 Mikhail George

Among the genes downregulated by more than 1.4-fold, a significant enrichment of functional pathways related to caveola, cytoskeleton organization, blood vessel and coagulation, as well as chromosomal proteins was observed

Liver (hepatic) and kidney safety considerations are equally important, since some supplements that undergo hepatic metabolism or renal excretion can accumulate or interact with chemotherapeutic drugs leading to hepatotoxicity (e.g., kava, high-dose green tea extract) or nephrotoxicity in patients who already suffer from impaired organ function or taking chemotherapy agents known to be nephrotoxic such as cisplatin (208, 209)

Excessive consumption can lead to bloating, stomach cramps, and diarrhea

doi: 10.1007/s002530100616 54 AmedeiAMorbidelliL

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