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For example, while FGF21 stimulates sympathetic activation in mice, elevations in cortisol that would suggest hypothalamic-pituitary-adrenal activation have not been observed in monkeys (239)

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Depletion of NADPH impairs NO synthesis and lowers glutathione levels, causing an overproduction of oxygen free radicals, which compromises endothelial cell function in blood vessels (Odai et al., 2019

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