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VAS, visual analog scale

A 2014 mouse study found that NAC and vitamin E accelerated lung tumor progression and reduced survival.41 A 2015 melanoma mouse study found that NAC increased lymph node metastases in mice with malignant melanoma.42 A 2019 mouse study reported that NAC protected against emphysema-related lung damage but also induced lung adenocarcinoma in some mice.43 And a 2021 hepatocellular carcinoma study found that antioxidant supplements including NAC promoted tumor formation, growth, and drug resistance in experimental models by reducing intracellular ROS.3 Newer human data add another layer of complexity

Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity

These changes in mitochondrial morphology alter its function disrupting the balance of OXPHOS, ATP production and changing cellular energy metabolism (130)

Acta Otolaryngol

To sum up, ROS act as a junction in the action of DKD-induced ferroptosis