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However, the presence of conserved helicase motifs does not necessarily implicate unwinding activity that can be detected in vitro 85 , which has been demonstrated for Coronaviridae Nsp13 (53) 86 , Alphaviruses Nsp2 (53) 87 , Flaviviridae NS3 (35) 88,89 , hepatitis E virus ORF1 (53) 90 and others

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