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Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane

Thirty-four patients, diagnosed with AIS and receiving reperfusion therapy, were given a dose-escalation of C+P (10/20/50/100 mg) or placebo intravenously at the beginning of endovascular thrombectomy

(2017) JNK activation turns on LPS and Gram-negative bacteria-induced NADPH oxidase-dependent suicidal NETosis, Sci

These data suggest membrane-bound dipeptidase deficiency [47]

These thiols form S-nitrosoglutathione (GSNO) and SNO upon direct interaction with NO and by transnitrosation reactions with other SNO proteins [180]

In the liver, insulin inhibits glucose production and release, by blocking gluconeogenesis and glycogenolysis through the regulation of expression of phosphoenolpyruvate carboxylase (PEPCK) [17]